• Biotechnology company Triplebar and cultivated seafood platform company Umami Meats signed a letter of intent to collaborate on development of cell lines for sustainable cultivated seafood � starting with Japanese eel
• Together, teams will improve the fitness and performance of cell lines to enable lower-cost, more efficient production of cultivated fish, reducing supply-chain risks, and relieving pressure on decimated fish stocks
• An increasingly popular ingredient for sushi and other Japanese dishes, eels are critically endangered in the wild, and eel aquaculture is unsustainable due to reliance on wild-caught glass eels

EMERYVILLE, Calif. & SINGAPORE--(BUSINESS WIRE)--Biotechnology company Triplebar and cultivated seafood platform company Umami Meats are partnering to co-develop optimized cell lines suitable for large-scale production of cultivated seafood � starting with one of the most popular and critically endangered fish species.

Emeryville, Calif.-based Triplebar and Singapore-headquartered Umami Meats signed a letter of intent this month to collaborate on shared technical milestones, with the unified mission of producing commercially viable, scalable, and affordable cultivated seafood. Their first project will be Japanese eel.

Together, Triplebar and Umami teams will work to improve the fitness and performance of cell lines to enable lower-cost, more efficient production of cultivated foods. The shared goal is to reduce the cost of high-quality foods, reduce supply-chain risks in the global fishing and aquaculture industry, and relieve pressure on depleted fish stocks in the world�s oceans.

�The solution to the global seafood problem is to leverage science and technology to make high-quality food affordably and sustainably,� said Maria Cho, CEO of Emeryville, Calif.-based Triplebar. �Biotechnology can make our global food system more robust, and relieve pressure on the ecosystem, which is facing a catastrophic collapse in biodiversity.�

Unagi: A delicious and devastating delicacy

The first product to be commercialized under the new letter of intent is Japanese eel, or unagi, native to the waters off Japan, Korea, China, Vietnam and the Philippines. It�s considered an essential part of Japanese cuisine, common in sushi, poke and grilled main courses.

But due to overfishing, the surge in ocean temperatures, and ocean acidification, unagi has become critically endangered in the wild. Aquaculture for carnivorous eels is resource-intensive and environmentally hazardous: It takes 2.5 tons of wild fish to generate 1 ton of marketable eels. Pathogen-susceptible eels escape from aquaculture systems, many of which use open tanks in modified wetlands � leading to wetland destruction, and crossbreeding between wild and sick domesticated stock.

Umami Meats will leverage Triplebar�s Hyper-Throughput� screening system for solution discovery, testing millions of potential phenotypic solutions in the time it normally takes to search mere hundreds. The partners will work together to develop a licensing agreement that will accelerate cell line development and optimization without the need for genetic modification.

Triplebar uses its proprietary integration of hardware, software, biology and biochemistry as the microprocessor for biology, bringing the powerful algorithm of evolution to develop products and biological production systems used to produce them in the lab. Triplebar�s technology can be easily applied to food, pharmaceuticals and other verticals.

Triplebar announced a partnership in January with global ingredients giant FrieslandCampina to co-develop and scale up the production of ingredients essential to human nutrition. Together, Triplebar and FrieslandCampina will produce microbial cells via fermentation methodologies � which, at scale, can produce proteins with a much smaller land, water and energy footprint than traditional livestock.

Triplebar is a foundry business of The Production Board (TPB), a venture foundry established to solve the most fundamental problems that affect our planet. TPB is the primary investor in Triplebar and is reimagining and re-engineering global production systems across food, agriculture, biomanufacturing, human health and the broader life sciences. Founded by Dave Friedberg, TPB conducts deep scientific and technical research to identify emerging and meaningful discoveries and determine whether they have transformational commercial applications.

Leveraging Science and Capital to Build a Future of Abundance

Umami Meats is developing the operating system for cultivated seafood, a standardized, modular production process that empowers seafood producers to locally manufacture a range of delicious, affordable, and healthy cultivated seafood products tailored to local consumer tastes. Umami Meats is enabling a sustainable alternative to wild-caught and farmed fish that is better for people, marine life, and the planet at large.

Umami Meats has established a novel production process built around cell types which can rapidly produce mature muscle and fat. The company is now working to optimize production architecture and process design to reduce costs, increase productivity, and establish a reliable, repeatable process that can scale at production sites around the world.

Through the unique combination of stem cell biology, machine learning, and digital twins, Umami Meats is pioneering the development of a standardized, modular, and automated production process that can produce cultivated seafood from a variety of fish species. Building partnerships that accelerate the process development cycle and improve product quality has been a core priority for the company over the past year.

�We are firm believers in technology as a tool to make seafood better, healthier, and more sustainable than conventional aquaculture and wild catch, especially for endangered species. So we are delighted when we find the opportunity to partner with other businesses that share our vision and that have technologies that can accelerate our progress toward achieving it,� said Mihir Pershad, CEO of Umami Meats. �I�m certain that this collaboration between Umami Meats and Triplebar will accelerate the commercialization of cultivated seafood and the transition to a more robust and sustainable food system for everyone.�

With the goal of restoring ocean ecosystems and preserving biodiversity, Umami Meats� product roadmap prioritizes the world�s most popular seafoods from species that are IUCN Red Listed, unsuited to large-scale aquaculture, and facing growing demand. Last year, the company debuted the world�s first cultivated fish ball laksa, fish cakes, and fish tacos at a series of private tasting events in Singapore to showcase cultivated seafood�s potential to preserve heritage dishes and culinary traditions while alleviating pressure on our oceans.

Umami and Triplebar plan to announce additional details of their agreement later this year.

About Triplebar (https://www.triplebar.com):

Triplebar Bio, Inc. (TBB) is solving the biggest problems threatening our food and healthcare systems by developing products to improve nutrition and disease treatment outcomes. We harness the power of evolution to allow nature to do what it does best � to design the perfect solution to biological problems. We capture this power through miniaturizing evolution in a proprietary, hyper-throughput screening platform where microfluidics and hyperspeed testing give us access to product and manufacturing design space that has never been realized. Triplebar is a multi-product, multi-vertical, product design engine. For food and nutrition we focus on bioactives, functional food proteins and cultured meat and for healthcare we focus on novel biologics against either validated targets or previously undruggable targets. Discover more about what we can do at www.triplebar.com.

About Umami Meats: (https://www.umamimeats.com)

Umami Meats is developing the operating system for cultivated seafood, empowering seafood producers around the world to locally manufacture a range of delicious, affordable, and healthy cultivated seafood products tailored to local consumer tastes. We are dedicated to regenerating our oceans and our planet by enabling consumers to have their fish and eat it too, starting with IUCN�s (International Union for Conservation of Nature) Red Listed species that are unsuited to commercial aquaculture and are being driven extinct by human consumption.

Through the unique combination of stem cell biology, machine learning, and digital twins, Umami Meats is pioneering the development of a standardized, modular, and automated production process that can produce affordable, delicious cultivated seafood from a variety of fish species. The company�s cultivated seafood production system will enable a stable, resilient, local supply of seafood free from mercury, antibiotics, microplastics and ocean pollutants.

Contacts

Jon Hanley, Triplebar Bio

[email protected]