Categories: Wire Stories

LegoChem Biosciences Selects BostonGene as Genomic Partner for First-in-Human Clinical Trial

BostonGene to Support Phase 1/2 Clinical Trial of TROP2-Directed Antibody-Drug Conjugate (ADC) in Patients with Advanced Cancers

WALTHAM, Mass.–(BUSINESS WIRE)–BostonGene, a leading provider of AI-driven, molecular and immune profiling solutions, and LegoChem Biosciences, Inc. (LCB), a clinical-stage biopharmaceutical company developing next-generation, antibody-drug conjugates (ADCs), announced a collaboration to support the Phase I/II study of LCB84, a TROP2-directed ADC, in patients with advanced cancers. This first-in-human study is being conducted at leading cancer institutions in the US and Canada to evaluate the safety and preliminary efficacy of LCB84, both as a single-agent therapy and in combination with an immune checkpoint inhibitor (anti-PD-1 antibody).


“We partnered with BostonGene in order to validate theorized mechanisms of ADC efficacy and uncover novel biomarkers to improve patient selection as LegoChem Biosciences progresses towards further clinical validation of our ADC platform technology, enabling safer and more efficacious therapies for cancer patients,” said Director of Drug Development Stephen Slocum, PhD at LegoChem Biosciences. “BostonGene’s integrated analytic and AI capabilities will provide us with crucial insights towards developing breakthrough cancer treatments.”

“We are excited to collaborate with LCB to support the development of their novel, TROP2-directed ADC, LCB84, and to address the high unmet need in cancer for improved tumor targeting, safety and efficacy,” said Andrew Feinberg, President and CEO at BostonGene.

Added Chief Medical Officer Nathan Fowler, MD, “BostonGene’s proprietary discovery platform merges a deep understanding of the human immune system and cancer biology with unparalleled software expertise and capacity. With a pragmatic, results-oriented team approach, we are driven by the potential for a direct impact on the lives of cancer patients. Our accelerated biomarker discovery algorithms support optimized “matching” of patients with therapies that can effectively target the unique characteristics of their cancer.”

BostonGene will serve as the study’s central laboratory and analytic partner for exploratory biomarkers, performing in-depth, multi-omic profiling of patients’ tumor tissue and blood samples, including whole-exome sequencing (WES), whole-transcriptome sequencing (RNAseq) of tumor tissue from matched tumor biopsies on the study, and immunoprofiling to identify hundreds of different cell types from a single blood sample. Leveraging its advanced AI and machine learning platforms, BostonGene will also deliver comprehensive analytics to identify predictive biomarkers and optimize the selection of patients most likely to benefit from treatment.

Each patient’s tumor has a unique molecular “fingerprint” that can be identified with BostonGene’s differentiated analytic and software platforms for comprehensive, real-time, cost-efficient results to support the delivery of highly personalized cancer therapies that give patients the best chance of durable responses.

About BostonGene Corporation

BostonGene has a mission to provide transformative, AI-integrated molecular analytics and biomarker discovery for precision matching of therapies to improve the lives of patients living with cancer and other immune-related diseases. BostonGene’s concierge-service model provides customized client solutions using a multi-omic approach prioritized for real-world impact to optimize standard-of-care therapies, accelerate research and provide cost-effective, measurable data-driven results. BostonGene’s testsreveal key drivers of each patient’s unique disease profile, including an in-depth profile of the immune microenvironment, actionable mutations, biomarkers of response to diverse therapies, and recommended therapies. Through these comprehensive analyses, BostonGene’s tests generate a personalized roadmap for therapeutic decision-making for each patient. For more information, visit BostonGene at http://www.BostonGene.com.

About LegoChem Biosciences, Inc.

LegoChem Biosciences, Inc. (LCB, KOSDAQ: 141080), is a clinical-stage biopharmaceutical company dedicated to the discovery and development of next-generation novel therapeutics utilizing its proprietary medicinal drug discovery technology LegoChemistry and ADC platform technology ConjuAll. Since its foundation in 2006, LCB has focused on the research and development of Antibody-Drug-Conjugates (ADCs), anticancer therapeutics, antibiotics and anti-fibrotics based on proprietary platform technologies. For more information, visit LegoChem Biosciences, Inc. at https://legochembio.com.

Contacts

Media:

BostonGene
Erin O’Reilly

+1-617-283-2285

Erin.Oreilly@BostonGene.com

LegoChem Biosciences
Daeyoung Jeong

+82-42-861-0688

jdy@legochembio.com

Alex

Recent Posts

China Focus: Technology sows seeds of hope in combating desertification

HOHHOT, CHINA - Media OutReach Newswire - 23 December 2024 - China's National Forestry and…

5 minutes ago

Novautek Honored with the “Outstanding SME ESG and Business Performance Award”

HONG KONG SAR - EQS Newswire - 23 December 2024 - Novautek Autonomous Driving Limited…

2 hours ago

V-GREEN and Xanh SM Indonesia sign MoU with Lippo for comprehensive green ecosystem in Indonesia

JAKARTA, INDONESIA - Media OutReach Newswire - 23 December 2024 - V-GREEN and PT Xanh…

3 hours ago

Molex Anticipates Steady Growth in High-Speed Connectivity in 2025, Driving Electronics Design Innovations Across Diverse Industry Sectors

Increase in opportunities predicted for high-speed optical transceivers and miniaturized connectivity solutions to address data-intensive…

5 hours ago

Celebrating 25 Years of Excellence: DYXnet Embarks the New Chapter of Digital Transformation

HONG KONG SAR - Media OutReach Newswire - 23 December 2024 - DYXnet, a wholly-owned…

5 hours ago

The Top 10 Best Places to Work in Egypt for 2024 revealed

CAIRO, EGYPT - Media OutReach Newswire - 23 December 2024 - Eand, Novo Nordisk, BSH,…

7 hours ago