Categories: Wire Stories

HighField Biopharmaceuticals Announces First Patient Dosed in Phase 1b/2 Trial of HF1K16 for Recurrent and Refractory Glioma

HF1K16 is a new immuno-oncology drug targeting myeloid-derived suppressor cells (MDSC) to treat cancer

HANGZHOU, CHINA–(BUSINESS WIRE)–HighField Biopharmaceuticals (HighField Bio), a clinical stage immuno-oncology company using immunoliposomes to treat cancer, announced today the first patient has been dosed in a Phase 1b/2 trial of HF1K16 for recurrent and refractory glioma. HF1K16 is a drug encapsulated immune modulating liposome containing all-trans retinoic acid (ATRA).


“This clinical trial follows our analysis of interim data from a Phase 1a study in which three out of five glioma patients responded to the single agent treatment. One achieved complete response (CR) and two more had stable disease (SD) diagnosis,” said Yuhong Xu, CEO of HighField Bio.

“That Phase 1a study is ongoing, and based on this promising clinical data, we are conducting a Phase 1b/2 trial that will enroll patients with recurrent and refractory glioma intended to establish the statistical significance of HF1K16’s efficacy,” Dr. Xu added.

Incidence of glioma worldwide varies by region and according to the American Society of Clinical Oncology an estimated 22,000 people in the U.S. will be diagnosed in 2023. Glioblastoma is the most common glioma and the most deadly. The patients with recurrent and refractory gliomas enrolled in HighField’s Phase 1b/2 trial have failed all other treatments.

HF1K16 is a unique liposome construct of ATRA, a small molecule metabolite of vitamin A. Administered by infusion, HF1K16 travels through the blood stream and infiltrates the tumor microenvironment. ATRA is released and initiates the maturation of myeloid-derived suppressor cells (MDSCs).

MDSCs are immature myeloid cells. ATRA promotes the maturation and differentiation of MDSCs into functional cells, such as dendritic cells, which then summon T cells to attack the cancer.

HighField is developing next generation drug encapsulated immune modulating liposomes and cancer targeted immunoliposomes that are less toxic and more effective than existing immune-oncology drugs. In addition, the liposome constructs are more efficient so that the material costs to manufacture are much lower. This also could lead to lower priced therapies.

The Phase 1b/2 trial will be conducted in China and will assess safety and efficacy as well as evaluate changes in MDSC numbers and phenotypes. See NCT05388487 at clinicaltrials.gov.

About HighField Biopharmaceuticals

Highfield Bio is a clinical stage immuno-oncology company focused on novel applications of liposome constructs to disrupt existing immuno-oncology technologies. The company has a research and development center and a GMP-compliant production facility. HighField Bio’s lead clinical development program is HF1K16, a drug encapsulated immune modulating liposome containing all-trans retinoic acid targeting myeloid-derived suppressor cells for treatment of solid tumors. For more information visit https://highfield.bio.

Contacts

Media Contact:

Dan Eramian

Opus Biotech Communications

danieleramian@comcast.net
425-306-8716

Business Development Contact:

Donald Wyatt

HighField Biopharmaceuticals

dwyatt@hf-biopharm.com
206-356-8196

Alex

Recent Posts

China Focus: Technology sows seeds of hope in combating desertification

HOHHOT, CHINA - Media OutReach Newswire - 23 December 2024 - China's National Forestry and…

9 hours ago

Novautek Honored with the “Outstanding SME ESG and Business Performance Award”

HONG KONG SAR - EQS Newswire - 23 December 2024 - Novautek Autonomous Driving Limited…

11 hours ago

V-GREEN and Xanh SM Indonesia sign MoU with Lippo for comprehensive green ecosystem in Indonesia

JAKARTA, INDONESIA - Media OutReach Newswire - 23 December 2024 - V-GREEN and PT Xanh…

12 hours ago

Molex Anticipates Steady Growth in High-Speed Connectivity in 2025, Driving Electronics Design Innovations Across Diverse Industry Sectors

Increase in opportunities predicted for high-speed optical transceivers and miniaturized connectivity solutions to address data-intensive…

14 hours ago

Celebrating 25 Years of Excellence: DYXnet Embarks the New Chapter of Digital Transformation

HONG KONG SAR - Media OutReach Newswire - 23 December 2024 - DYXnet, a wholly-owned…

14 hours ago

The Top 10 Best Places to Work in Egypt for 2024 revealed

CAIRO, EGYPT - Media OutReach Newswire - 23 December 2024 - Eand, Novo Nordisk, BSH,…

16 hours ago