New biomarkers found for diagnosis and treatment of triple-negative breast cancer
KYOTO, Japan–(BUSINESS WIRE)–COGNANO, Inc. (Kyoto, Japan) and associates announced the discovery of a panel of antibodies specific for triple-negative breast cancer (TNBC). Breast cancer was the second leading cause of death for American women in 2022. To date, the three markers (Her2, ER and PgR) have been used for diagnosis that has increased life expectancy for many patients. However, patients with low expressions of these markers are diagnosed with TNBC and have the worst prognosis. The authors obtained a panel of antibodies indicating TNBC cancer cells through a computational approach using the genetic database from immunized alpacas. The results also signify the discovery of multiple new target molecules suitable for TNBC treatment. The authors mention COGNANO’s algorithm can discover therapeutic targets to solve any malignancies defined as unmet medical needs.
The research was published on the bioRxiv preprint server on February 23, 2023.
Title: Statistical mining of triple-negative breast cancer-specific nanobodies among huge libraries from immunized alpacas.
Authors: Ryota Maeda, Hiroyuki Yamazaki, Ryoga Kobayashi, Seishiro Yamamoto, Kazuki Kasai, Akihiro Imura* (*Correspondence author)
DOI: 10.1101/2023.02.23.529685
URL: https://www.biorxiv.org/content/10.1101/2023.02.23.529685v1
Glossary
VHH antibody
Abbreviation for Variable domain (VH) of heavy chain antibody. Ordinary antibodies consist of a combination of two chains, but camelid animals such as alpacas have unique antibodies consisting of only heavy chains, and even if only the antigen-binding site (VH) is taken out, the antigen-binding activity is still retained, it has attracted attention as a VH domain of heavy chain, that is, a small VHH antibody.
Big data
A huge data group that is difficult for humans to grasp as a whole. In biotechnology, genome sequences and vast numbers of mRNA sequences, which correspond to blueprints for highly diverse antibody molecules, are equivalent to big data. When an alpaca is inoculated with an antigen (in this case, the coronavirus spike protein), it produces billions or more of VHH antibodies against that antigen. From this big library (like choosing a book in a library), it is necessary to devise a way to select practically suitable ones in a short time. Developed and patented.
Contacts
COGNANO, Inc.
Akihiro Imura, +81-75-741-6962
cognano@cognano.co.jp
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